Title : [Relationship between expression of STAT3 gene and proliferation of rat pulmonary arterial smooth muscle cells under hypoxia conditions].

Pub. Date : 2006 Feb

PMID : 21186585






1 Functional Relationships(s)
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1 RESULTS: The level of tyrosine-phosphorylated STAT3 increased at 6 h and peaked at 12 h. The expression of c-myc mRNA increased after 2 h of hypoxia and reached maximal level at 4 h, then declined at 6 h and to the basal levels at 12 h. With the prolonging of hypoxia time, 3H-TdR incorporation in PASMC under hypoxia conditions was significantly higher. pasmc MYC proto-oncogene, bHLH transcription factor Rattus norvegicus