Pub. Date : 2010 Nov 1
PMID : 21182472
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of note, rapamycin and FK506 bind to FKBP12, and the resulting complexes interfere with distinct intracellular signaling pathways driven, respectively, by the mammalian target of rapamycin and calcineurin phosphatase. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 2 | Interestingly, derivatives of FK506 that have the same FKBP12-binding properties as FK506 but lack functional immunosuppressant activity, exert the same apoptotic effect as FK506 in chronic lymphocytic leukemia.These findings suggest that a direct FKBP inhibition represents a further mechanism of immunosuppressants." | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |