Pub. Date : 2010 Dec
PMID : 21175442
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Finally, a panel of human liver microsomes (genotyped for UGT1A1*28 allele status) was used to determine the importance of UGT1A1 in the direct glucuronidation of repaglinide. | repaglinide | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 2 | UGT1A1 plays a significant role in the glucuronidation of repaglinide. | repaglinide | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 3 | CONCLUSIONS: Inhibition of UGT enzymes, especially UGT1A1, by gemfibrozil and its glucuronide is an additional mechanism to consider when rationalizing the interaction between repaglinide and gemfibrozil. | repaglinide | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |