Title : Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus.

Pub. Date : 1990 Aug 20

PMID : 2117385






5 Functional Relationships(s)
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1 The early studies, which were performed in patients receiving concomitant insulin therapy, may have underestimated the true effect of glyburide on insulin secretion. Glyburide insulin Homo sapiens
2 The effects of glyburide on insulin secretory rates calculated from plasma C-peptide levels were recently evaluated using individually derived C-peptide kinetic parameters and a validated open two-compartment model of peripheral C-peptide kinetics. Glyburide insulin Homo sapiens
3 During that time, insulin secretion rates increased by 221 percent in response to glyburide. Glyburide insulin Homo sapiens
4 In the patients receiving glyburide, the sluggish insulin secretory response to breakfast persisted, and the insulin secretory response during the hyperglycemic clamping was less than the response normally seen in nondiabetic subjects. Glyburide insulin Homo sapiens
5 In the patients receiving glyburide, the sluggish insulin secretory response to breakfast persisted, and the insulin secretory response during the hyperglycemic clamping was less than the response normally seen in nondiabetic subjects. Glyburide insulin Homo sapiens