Title : Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species.

Pub. Date : 2011 Feb 15

PMID : 21173077






2 Functional Relationships(s)
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1 We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens
2 Importantly, co-treatment of RA with TPA or TGF-beta further stimulated ROS production in a fashion that positively correlated with levels of VEGF secretion. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Homo sapiens