Pub. Date : 2011 Feb 15
PMID : 21173077
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 2 | We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 3 | Importantly, co-treatment of RA with TPA or TGF-beta further stimulated ROS production in a fashion that positively correlated with levels of VEGF secretion. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 4 | The antioxidants N-acetylcysteine and glutathione monoethyl ester inhibited both RA + TPA and RA + TGF-beta-stimulated secretion of VEGF, as well as RA-induced ROS production. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |