Title : Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

Pub. Date : 1990 Aug

PMID : 2117277






1 Functional Relationships(s)
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1 Upon exposure to either chemotactic peptide (FMLP), phorbol 12-myristate 13-acetate, or an ionophore (A23187), 15-HETE-labeled PMNs released 15-HETE from phosphatidylinositol and displayed an impaired ability to generate leukotriene B4 (LTB4), 20-OH-LTB4, and 20-COOH-LTB4. 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid formyl peptide receptor 1 Homo sapiens