Title : The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.

Pub. Date : 2011 Feb

PMID : 21171079






2 Functional Relationships(s)
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1 The EGFR inhibitor tyrphostin (AG 1478) markedly inhibited proliferation of the chordoma cell line U-CH1 in vitro and diminished EGFR phosphorylation in a dose-dependant manner, a finding supported by inhibition of phosphorylated Erk1/2. Tyrphostins epidermal growth factor receptor Homo sapiens
2 The EGFR inhibitor tyrphostin (AG 1478) markedly inhibited proliferation of the chordoma cell line U-CH1 in vitro and diminished EGFR phosphorylation in a dose-dependant manner, a finding supported by inhibition of phosphorylated Erk1/2. Tyrphostins epidermal growth factor receptor Homo sapiens