Title : Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.

Pub. Date : 2011 Jan 1

PMID : 21163664






1 Functional Relationships(s)
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1 From these X-ray co-crystallography results, to achieve more potent inhibitory activity, we targeted Arg125 as a potential amino acid residue because it was located near the pyridine core, and some known DPP-4 inhibitors were reported to interact with this residue. pyridine dipeptidyl peptidase 4 Homo sapiens