Title : Immunophilin deficiency augments Ca2+-dependent glutamate release from mouse cortical astrocytes.

Pub. Date : 2011 Jan

PMID : 21163525






1 Functional Relationships(s)
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1 Furthermore, acute treatment with CsA to inhibit CypD modulation of mitochondrial Ca(2+) buffering, or with FK506 to inhibit FKBP12 interaction with inositol-trisphosphate receptor of the endoplasmic reticulum, led to similar reductive effects on astrocytic Ca(cyt)(2+) dynamics, but also to an enhanced Ca(2+)-dependent exocytotic release of glutamate in wild-type astrocytes. Tacrolimus FK506 binding protein 1a Mus musculus