Title : Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.

Pub. Date : 2011 Dec

PMID : 21161716






1 Functional Relationships(s)
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1 Different negative allosteric modulators (NAMs) of mGluR5 were repeatedly shown to be efficacious in models of L: -DOPA-induced dyskinesia (LID), anxiety, and some forms of pain. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus