Title : ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation.

Pub. Date : 2010 Dec 2

PMID : 21152039






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-kappaB activation. Lipid A toll-like receptor 4 Mus musculus
2 CONCLUSIONS/SIGNIFICANCE: Our findings indicate that ATF3 deficiency affects Kdo(2)-Lipid A-induced TLR4 signaling pathways in MEF cells, that it may upregulate IkappaBzeta expression and that the high levels of IkappaBzeta expression in ATF3-/- cells disrupts Kdo(2)-Lipid A-mediated signaling pathways. Lipid A toll-like receptor 4 Mus musculus