Title : Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells.

Pub. Date : 2010 Nov 18

PMID : 21139994






1 Functional Relationships(s)
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1 RESULTS: To reveal primary effects, we examined digitoxin"s effect 6 h post-treatment with the highest dose, 1mug/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. Digitoxin H3 histone pseudogene 16 Homo sapiens