Pub. Date : 2010
PMID : 21136335
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of NF-kappaB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts. | Dimethyl Fumarate | interleukin 6 | Homo sapiens |
| 2 | PDGF-BB and TNF-alpha induced IL-6 secretion by lung fibroblasts and this was inhibited by DMF in a dose-dependent manner. | Dimethyl Fumarate | interleukin 6 | Homo sapiens |
| 3 | CONCLUSIONS: Our data suggest that DMF down-regulates TNF-alpha-induced IL-6 secretion and proliferation by inhibiting NF-kB and AP-1 activity, indicating its potential beneficial use for the treatment of inflammatory lung diseases. | Dimethyl Fumarate | interleukin 6 | Homo sapiens |