Title : The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus.

Pub. Date : 2011 Feb 1

PMID : 21134422






2 Functional Relationships(s)
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1 The aims of this study were to investigate the change in short and long term memory as assessed by the novel object recognition (NOR) test and BDNF expression in hippocampus produced by an acute hypoglutamatergic model of memory impairment in schizophrenia induced by administration of the NMDA receptor non-competitive antagonist, MK-801 and the ability of clozapine and NDMC to prevent the deleterious effects of MK-801. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus
2 The aims of this study were to investigate the change in short and long term memory as assessed by the novel object recognition (NOR) test and BDNF expression in hippocampus produced by an acute hypoglutamatergic model of memory impairment in schizophrenia induced by administration of the NMDA receptor non-competitive antagonist, MK-801 and the ability of clozapine and NDMC to prevent the deleterious effects of MK-801. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus