Title : CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

Pub. Date : 2011 Jan

PMID : 21131960






3 Functional Relationships(s)
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1 Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). Threonine cyclin dependent kinase 1 Homo sapiens
2 Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). Threonine cyclin dependent kinase 1 Homo sapiens
3 In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of EZH2 at Thr 487. Threonine cyclin dependent kinase 1 Homo sapiens