Title : Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.

Pub. Date : 2011 Jan

PMID : 21131601






2 Functional Relationships(s)
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1 In HaCaT and BJAB, two TGF-beta-sensitive cell lines, which had higher basal levels of phospho-MEK and TbetaRII compared with RL, U0126 induced downregulation of TbetaRII and blocked subsequent TGF-beta signaling. U 0126 transforming growth factor beta 1 Homo sapiens
2 In HaCaT and BJAB, two TGF-beta-sensitive cell lines, which had higher basal levels of phospho-MEK and TbetaRII compared with RL, U0126 induced downregulation of TbetaRII and blocked subsequent TGF-beta signaling. U 0126 transforming growth factor beta 1 Homo sapiens