Title : Anaplerotic role for cytosolic malic enzyme in engineered Saccharomyces cerevisiae strains.

Pub. Date : 2011 Feb

PMID : 21131518






1 Functional Relationships(s)
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1 When PDC2, a transcriptional regulator of pyruvate decarboxylase genes, was deleted to increase intracellular pyruvate levels and cells were grown under a CO(2) atmosphere to favor carboxylation, adaptive evolution yielded a strain that grew on glucose (specific growth rate, 0.06 +- 0.01 h(-1)). Pyruvic Acid Pdc2p Saccharomyces cerevisiae S288C