Title : Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.

Pub. Date : 2011 Feb 7

PMID : 21130714






1 Functional Relationships(s)
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1 Treatment of PARP-1-expressing cells with the combination of a DNA methylating agent (MMS) and the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN) leads to an ATR/Chk1-dependent S phase checkpoint and cell death by apoptosis. Methyl Methanesulfonate ATR serine/threonine kinase Homo sapiens