Title : Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects.

Pub. Date : 2011 Feb

PMID : 21127283






3 Functional Relationships(s)
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1 Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Morphine catechol-O-methyltransferase Homo sapiens
2 In this study, we investigated whether combined catechol-O-methyltransferase and mu-opioid receptor polymorphisms contribute to the morphine response in postoperative analgesia. Morphine catechol-O-methyltransferase Homo sapiens
3 RESULTS: The heterozygous patients with mu-opioid receptor A118G and catechol-O-methyltransferase G1947A mutation consumed significantly less morphine in the postanesthetic recovery room and 48 hours after surgery compared with homozygous patients of the A118 variant. Morphine catechol-O-methyltransferase Homo sapiens