Pub. Date : 2011 Jan 13
PMID : 21124315
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (ROS) derived from an uncharacterized organelle. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (ROS) derived from an uncharacterized organelle. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Here we show that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |