Title : Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations.

Pub. Date : 2011 Feb 1

PMID : 21111724






2 Functional Relationships(s)
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Protein Name
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1 Indirubin-3"-oxime, 6-Br-indirubin-3"-oxime, alsterpaullone and kenpaullone increased LNCaP cell proliferation and PSA expression (0.03-1 muM; apoptosis occurred >1 muM), whereas aminopurvalanol significantly (p<0.05) reduced DHT-stimulated PSA expression (31%) at 1 nM. kenpaullone kallikrein related peptidase 3 Homo sapiens
2 Indirubin-3"-oxime, 6-Br-indirubin-3"-oxime, alsterpaullone and kenpaullone increased LNCaP cell proliferation and PSA expression (0.03-1 muM; apoptosis occurred >1 muM), whereas aminopurvalanol significantly (p<0.05) reduced DHT-stimulated PSA expression (31%) at 1 nM. kenpaullone kallikrein related peptidase 3 Homo sapiens