Title : Development of RET kinase inhibitors for targeted cancer therapy.

Pub. Date : 2011

PMID : 21110809






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RET protein comprises an extracellular portion with four cadherine-like domains and a cysteine- rich region important for intermolecular interactions; a hydrophobic transmembrane domain; an intracellular part comprising the juxtamembrane domain with regulatory function and the catalytic domain that phosphorylates the tyrosine residues of substrates. Cysteine ret proto-oncogene Homo sapiens