Title : Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells.

Pub. Date : 2011 Jan

PMID : 21109980






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1 In conclusion, these results indicate that the Ras/ERK1/2 pathway is mediated by the p27KIP1 induction, leading to a reduction in cyclin/CDK complexes in the esculetin-induced inhibition of colon cancer cell growth. esculetin cyclin dependent kinase inhibitor 1B Homo sapiens