Pub. Date : 2011 Sep
PMID : 21109419
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | T cell PPARgamma is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | The objective of this study was to investigate whether ABA"s anti-inflammatory efficacy in the gut is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) in T cells. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | The objective of this study was to investigate whether ABA"s anti-inflammatory efficacy in the gut is dependent on peroxisome proliferator-activated receptor gamma (PPARgamma) in T cells. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | ABA"s beneficial effects on disease activity were completely abrogated in T cell-specific PPARgamma null mice. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | Additionally, ABA improved colon histopathology, reduced blood F4/80(+)CD11b(+) monocytes, increased the percentage of CD4(+) T cells expressing the inhibitory molecule cytotoxic T lymphocyte antigen 4 in blood and enhanced the number of T(reg) cells in the mesenteric lymph nodes and colons of PPARgamma-expressing but not T cell-specific PPARgamma null mice. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | Additionally, ABA improved colon histopathology, reduced blood F4/80(+)CD11b(+) monocytes, increased the percentage of CD4(+) T cells expressing the inhibitory molecule cytotoxic T lymphocyte antigen 4 in blood and enhanced the number of T(reg) cells in the mesenteric lymph nodes and colons of PPARgamma-expressing but not T cell-specific PPARgamma null mice. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 7 | We conclude that dietary ABA ameliorates experimental inflammatory bowel disease by enhancing T(reg) cell accumulation in the colonic lamina propria through a PPARgamma-dependent mechanism. | Abscisic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |