Pub. Date : 2011 Mar 17
PMID : 21102517
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Homo sapiens |
| 2 | Further, reducing MMP-9 activity or expression significantly inhibits LPA-induced HCC cell invasion, demonstrating that MMP-9 is downstream of LPA1. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Homo sapiens |
| 3 | We thus demonstrate a mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades, providing novel biomarkers and potential therapeutic targets for HCC. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Homo sapiens |
| 4 | We thus demonstrate a mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades, providing novel biomarkers and potential therapeutic targets for HCC. | lysophosphatidic acid | lysophosphatidic acid receptor 1 | Homo sapiens |