Pub. Date : 2011 Jan 28
PMID : 21097842
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have discovered that arsenic trioxide (As(2)O(3)), a very potent antineoplastic compound for the treatment of acute promyelocytic leukemia, is proarrhythmic via two separate mechanisms: a well characterized inhibition of hERG/I(Kr) trafficking and a poorly understood increase of cardiac calcium currents. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
2 | We have discovered that arsenic trioxide (As(2)O(3)), a very potent antineoplastic compound for the treatment of acute promyelocytic leukemia, is proarrhythmic via two separate mechanisms: a well characterized inhibition of hERG/I(Kr) trafficking and a poorly understood increase of cardiac calcium currents. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |