Title : Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome.

Pub. Date : 2011 Jan 28

PMID : 21097842






3 Functional Relationships(s)
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1 We find that oxidative inactivation of the lipid phosphatase PTEN by As(2)O(3) enhances cardiac calcium currents in the therapeutic concentration range via a PI3Kalpha-dependent increase in phosphatidylinositol 3,4,5-triphosphate (PIP(3)) production. pip(3) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus
2 In guinea pig ventricular myocytes, even a modest reduction in PTEN activity is sufficient to increase cellular PIP(3) levels. pip(3) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus
3 Under control conditions, PIP(3) levels are kept low by PTEN and do not affect calcium current amplitudes. pip(3) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus