Title : Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro.

Pub. Date : 2011

PMID : 21092943






1 Functional Relationships(s)
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1 These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts. Poly I-C C-C motif chemokine ligand 2 Homo sapiens