Title : Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.

Pub. Date : 2011 Apr

PMID : 21091653






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1 KEY RESULTS: Both pre- and post-treatment with metformin significantly improved survival of animals during lethal endotoxaemia (survival rate was monitored up to 2 weeks), decreased serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta, HMGB1 expression and myeloperoxidase activity in lungs. Metformin interleukin 1 beta Mus musculus