Title : Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells.

Pub. Date : 2011 Feb

PMID : 21087080






1 Functional Relationships(s)
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1 Inhibition of HER1 with Gefitinib (5 muM) or Tyrphostin (AG1478) (20 muM) augmented the calcium-induced apoptosis, and with HER1 inhibition apoptosis was detectable after 6 h. Analysis of downstream signalling molecules showed an increased activation of Akt, PLCgamma and MAPK in response to calcium treatment. Tyrphostins latexin Homo sapiens