Title : STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest.

Pub. Date : 2010 Dec 1

PMID : 21084836






2 Functional Relationships(s)
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1 Interestingly, the STAT1 serine 727 phosphorylation site and not the STAT1 tyrosine 701 site is required for cyclin D1-dependent proteosomal degradation. Serine cyclin D1 Homo sapiens
2 Furthermore, IFN-gamma-STAT1 cyclin D1 reduction correlated with decreased amount of p-Rb Ser-795, cyclin E and increased amounts of the cell cycle inhibitors p27(Kip1) and p21(Cip1). Serine cyclin D1 Homo sapiens