Title : Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.

Pub. Date : 2011 Jun

PMID : 21083424






1 Functional Relationships(s)
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1 Here we show that HO-1-inducible effect by nicotine was mediated through sequential event-Ca(2+) influx, classical protein kinase C activation, and reactive oxygen species production-which activates phosphoinositol-3-kinase/Akt/Nrf-2 pathway. Nicotine thymoma viral proto-oncogene 1 Mus musculus