Pub. Date : 2011 Feb
PMID : 21081469
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine-mediated IkappaBalpha degradation and nuclear factor-kappa B (NF-kappaB) translocation dose-dependently. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Nicotine-mediated IkappaBalpha degradation and nuclear factor-kappa B (NF-kappaB) translocation dose-dependently. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Knockdown of NF-kappaB by short interfering RNA (siRNA) or specific inhibitor (Bay-11-7085) markedly suppressed nicotine-induced cell proliferation and upregulation of miR-16 and miR-21. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Interestingly, NF-kappaB-binding sites were located in both miR-16 and miR-21 gene transcriptional elements and we showed that nicotine enhanced the binding of NF-kappaB to the promoters of miR-16 and miR-21. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Interestingly, NF-kappaB-binding sites were located in both miR-16 and miR-21 gene transcriptional elements and we showed that nicotine enhanced the binding of NF-kappaB to the promoters of miR-16 and miR-21. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | EP2 or EP4 siRNA or antagonists impaired the nicotine-mediated NF-kappaB activity, upregulation of miR-16 and miR-21 and cell proliferation. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Taken together, these results suggest that miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. | Nicotine | nuclear factor kappa B subunit 1 | Homo sapiens |