Pub. Date : 1990 Feb
PMID : 2107864
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 2 | Dimethylthiourea (DMTU), a potent scavenger of hydroxyl radicals, was studied to see if it attenuated the inactivation of methionine synthase produced by nitrous oxide in mice. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 3 | These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 4 | These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 5 | Greater differences in methionine synthase activities between the DMTU- and saline-injected animals were observed with increasing doses of DMTU. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 6 | Greater differences in methionine synthase activities between the DMTU- and saline-injected animals were observed with increasing doses of DMTU. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 7 | DMTU exhibited its greatest effect in the kidney, where methionine synthase activities were nearly doubled in the DMTU 2.0 mg g-1-injected compared with the saline-injected mice after 1-h exposure to 66% nitrous oxide. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 8 | DMTU exhibited its greatest effect in the kidney, where methionine synthase activities were nearly doubled in the DMTU 2.0 mg g-1-injected compared with the saline-injected mice after 1-h exposure to 66% nitrous oxide. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |
| 9 | Following a marked inactivation of methionine synthase by exposing mice to 66% nitrous oxide for 4 h, injection of DMTU 2.0 mg g-1 at the end of exposure to nitrous oxide did not enhance, but impaired, the recovery of enzyme activity. | 1,3-dimethylthiourea | 5-methyltetrahydrofolate-homocysteine methyltransferase | Mus musculus |