Pub. Date : 2010 Dec 17
PMID : 21074517
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 7 | The effects of GB on Hsp90 were studied by characterizing its physical interactions with Hsp90 upon binding, the noncompetitive inhibition of Hsp90 ATPase activity, and the degradation of Hsp90 client proteins (i.e., Akt, IKK) in HeLa cells. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 8 | GB seems to bind to the N-terminal ATP-binding domain of Hsp90. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 9 | Thus, GB represents a promising therapeutic agent for cancer; it may also be useful as a probe to increase understanding of the biological functions of Hsp90. | gambogic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |