Pub. Date : 2010 Dec 17
PMID : 21074517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gambogic acid inhibits Hsp90 and deregulates TNF-alpha/NF-kappaB in HeLa cells. | gambogic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-alpha/NF-kappaB in HeLa cells. | gambogic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Additionally, GB suppresses the activation of TNF-alpha/NF-kappaB and decreases XIAP expression levels and the ratio of Bcl-2/Bax, which in turn induces HeLa cell apoptosis. | gambogic acid | nuclear factor kappa B subunit 1 | Homo sapiens |