Title : Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC.

Pub. Date : 2010 Nov 12

PMID : 21073732






1 Functional Relationships(s)
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1 RESULTS: Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro. Curcumin caspase 3 Mus musculus