Title : Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells.

Pub. Date : 2011 Feb

PMID : 21054790






3 Functional Relationships(s)
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1 Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells. fisetin tumor protein p53 Homo sapiens
2 In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-kappa B activity, causing a change in the ratio of pro- and anti-apoptotic proteins. fisetin tumor protein p53 Homo sapiens
3 Our study suggests that the activation of p53 and inhibition of the NF-kappa B system may play important roles in the fisetin-induced apoptosis in bladder cancer cells. fisetin tumor protein p53 Homo sapiens