Title : Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation.

Pub. Date : 2010 Dec 15

PMID : 21053344






1 Functional Relationships(s)
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1 Hydrogen peroxide enhanced vascular calcification by inducing osteoblastic differentiation of VSMCs, as showed by up-regulating the mRNA expression of type I collagen, osteocalcin, and Runx2, a key transcription factor for osteoblastic differentiation, increasing alkaline phosphatase activity, and calcium deposition. Hydrogen Peroxide RUNX family transcription factor 2 Homo sapiens