Title : Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease.

Pub. Date : 2010

PMID : 21052534






1 Functional Relationships(s)
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1 Based on an observation that PPARgamma agonists such as pioglitazone and rosiglitazone decrease mRNA levels of a Cl(-) transport protein, CFTR (cystic fibrosis transmembrane conductance regulator), and the Cl(-) secretory response to vasopressin in cultured renal cells, it is hypothesized that PPARgamma agonists will inhibit cyst growth. Pioglitazone arginine vasopressin Homo sapiens