Title : Elucidation of inositol hexaphosphate and heparin interaction sites and conformational changes in arrestin-1 by solution nuclear magnetic resonance.

Pub. Date : 2010 Dec 14

PMID : 21050017






3 Functional Relationships(s)
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1 Here we report the first successful use of solution NMR in mapping the binding sites in arrestin-1 (visual arrestin) for two polyanionic compounds that mimic phosphorylated light-activated rhodopsin: inositol hexaphosphate (IP6) and heparin. Phytic Acid S-antigen visual arrestin Homo sapiens
2 Here we report the first successful use of solution NMR in mapping the binding sites in arrestin-1 (visual arrestin) for two polyanionic compounds that mimic phosphorylated light-activated rhodopsin: inositol hexaphosphate (IP6) and heparin. Phytic Acid S-antigen visual arrestin Homo sapiens
3 IP6 and heparin appear to bind to the same site on arrestin-1, centered on a positively charged region in the N-domain. Phytic Acid S-antigen visual arrestin Homo sapiens