Title : AP-1/C-jun and C-myc Regulation During Megakaryocytic Differentiation of a Human Bi-potential Growth-factor-dependent Cell Line.

Pub. Date : 1995

PMID : 21043585






5 Functional Relationships(s)
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1 C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens
5 These studies suggest a link between PKC stimulation by TPA and AP-1 activation with downregulation of c-myc transcription on a molecular level. Tetradecanoylphorbol Acetate MYC proto-oncogene, bHLH transcription factor Homo sapiens