Pub. Date : 2011 Jan
PMID : 21042867
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we investigated the effect of an extract of V. africana and its constituents on smooth muscle contraction induced by capsaicin in mouse rectum, where transient receptor potential vanilloid type 1 (TRPV1)-immunoreactive fibers are abundant. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 2 | In the present study, we investigated the effect of an extract of V. africana and its constituents on smooth muscle contraction induced by capsaicin in mouse rectum, where transient receptor potential vanilloid type 1 (TRPV1)-immunoreactive fibers are abundant. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 3 | The capsaicin-induced contraction was almost completely inhibited by the TRPV1 antagonist, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC). | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |
| 4 | These results suggest that Iboga-type alkaloids isolated from V. africana inhibit capsaicin-induced contraction in the mouse rectum, possibly via the inhibition of a TRPV1-mediated pathway. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Mus musculus |