Pub. Date : 2010
PMID : 21042038
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro and in vivo inhibitory effects of glycyrrhetinic acid on cytochrome P450 3A activity. | Glycyrrhetinic Acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | We have assessed the ability of GA to inhibit the enzyme cytochrome P450 3A (CYP3A). | Glycyrrhetinic Acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | We have assessed the ability of GA to inhibit the enzyme cytochrome P450 3A (CYP3A). | Glycyrrhetinic Acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | A Lineweaver-Burk plot showed that GA was a mixed inhibitor of CYP3A, with an IC50 of 7.25 mumol/l, a K(m) of 4.3 mumol/l and a K(i) of 6.4 mumol/l by non-linear regression analysis. | Glycyrrhetinic Acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | CYP3A activity was also affected by intragastric administration of GA, which resulted in increases in area under the plasma concentration-time curve (AUC)(0-t) and in apparent elimination half-time (t1/2) and significant decreases in body clearance, as well as in the formation of 1-hydroxy-midazolam after intragastric or intravenous administration of midazolam (p < 0.05). | Glycyrrhetinic Acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |