Pub. Date : 2010 Nov 16
PMID : 21041644
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal mu- and kappa-opioid receptors (MOR and KOR, respectively). | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 2 | Cross-linking experiments in combination with in vivo pharmacological analyses indicate that heterodimeric MOR/KOR utilizes spinal dynorphin 1-17 as a substrate and is likely to be the molecular transducer for the female-specific KOR component of spinal morphine antinociception. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 3 | Cross-linking experiments in combination with in vivo pharmacological analyses indicate that heterodimeric MOR/KOR utilizes spinal dynorphin 1-17 as a substrate and is likely to be the molecular transducer for the female-specific KOR component of spinal morphine antinociception. | Morphine | opioid receptor kappa 1 | Homo sapiens |