Pub. Date : 2010 Sep
PMID : 21038848
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | In this study, we found that DADS-induced apoptosis in human leukemia HL-60 cells is mediated by ROS-activated JNK. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Activity of JNK was induced by DADS in a dose-dependent manner; HL-60 cells exposed to 10.0 mg/L DADS for 8 h showed maximum levels of phosphorylated JNK, which decreased when exposed for additional 4h. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Activity of JNK was induced by DADS in a dose-dependent manner; HL-60 cells exposed to 10.0 mg/L DADS for 8 h showed maximum levels of phosphorylated JNK, which decreased when exposed for additional 4h. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Activity of JNK was induced by DADS in a dose-dependent manner; HL-60 cells exposed to 10.0 mg/L DADS for 8 h showed maximum levels of phosphorylated JNK, which decreased when exposed for additional 4h. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Activity of JNK was induced by DADS in a dose-dependent manner; HL-60 cells exposed to 10.0 mg/L DADS for 8 h showed maximum levels of phosphorylated JNK, which decreased when exposed for additional 4h. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | N-Acetylcysteine (NAC), a known antioxidant, also decreased ROS generation, effectively blocked apoptosis, and decreased DADS-induced phosphorylated JNK levels. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | These results suggest that JNK is involved in DADS-induced ROS-mediated apoptosis in HL-60 cells. | diallyl disulfide | mitogen-activated protein kinase 8 | Homo sapiens |