Title : 5-fluorouracil-induced death of Jurkat T-cells--a role for caspases and MCL-1.

Pub. Date : 2010 Oct

PMID : 21036698






2 Functional Relationships(s)
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1 Previous studies with 5-FU suggest that proapoptotic protein BAX and tumor suppressor protein TP53 are central factors in this process. Fluorouracil tumor protein p53 Homo sapiens
2 Our results demonstrate the activation of alternative death pathways following treatment with 5-FU, despite mutations in the TP53 and BAX genes. Fluorouracil tumor protein p53 Homo sapiens