Pub. Date : 2010 Nov
PMID : 20977456
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes. | Imatinib Mesylate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Hepatic cytochrome P450 (CYP) 3A4 has been implicated in imatinib N-demethylation, but the clearance of imatinib decreases during prolonged therapy. | Imatinib Mesylate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CYP3A phenotype correlates with imatinib clearance at the commencement of therapy, but not at steady state. | Imatinib Mesylate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |