Title : Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.

Pub. Date : 2010 Nov

PMID : 20977456






1 Functional Relationships(s)
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1 KEY RESULTS: N-desmethylimatinib formation was correlated with microsomal oxidation of the CYP3A4 substrates testosterone (rho= 0.60; P < 0.01) and midazolam (rho= 0.46; P < 0.05), and the CYP2C8 substrate paclitaxel (rho= 0.58; P < 0.01). Paclitaxel cytochrome P450 family 3 subfamily A member 4 Homo sapiens